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Astrocytes BIOLOGIE MOLECULAIRE Myotonic Dystrophy Type 1 RNA splicing Cytoskeleton Gene therapy Therapy Dilated cardiomyopathy Brain ARN Astrocyte Mouse models Myostatin Exercise Autophagy Mouse model Fibrosis Myotonic Dystrophy CTG repeats Thérapie génique Desmin Maximal force Quantitative microdialysis Transgenic mouse Gene Therapy Trinucleotide Repeat Expansion Acetylcholinesterase knockout mouse Cultured Hypoxia Heart Endurance training Glucocorticoids Dynamin 2 Cardiac muscle RNA biology Transcriptomics Dystrophie myotonique Diaphragm Male Myotonic dystrophy DM1 RNA interference Neuron Muscular dystrophy Mice Cells Glucocorticoid-receptor Brain dysfunction Centronuclear myopathy Trinucleotide repeat expansion Long read sequencing Cell model CTG repeat contractions PacBio Humans DMSXL mice Aging Heart failure Cell penetrating peptide GSK3␤ ACETYLCHOLINESTERASE AAV CONGENITAL MYATHENIC SYNDROME Dystrophie Myotonique Antisense oligonucleotides Transgenic mouse model Oligodendrocytes Duchenne muscular dystrophy KNOCKOUT MICE Dystrophin CRISPRi MBNL Animals Exercice Myotonic dystrophy type 1 Myelin CMS Cell culture model CRISPR/Cas9 CTG repeat instability Oligodendrocyte Acetylcholinesterase deficiency Acute coronary syndrome Expression Myotonic dystrophy mouse models Genotype phenotype correlation Central nervous system DMPK Glutamate PCR Intermediate filament Motoneuron Gene editing Alternative splicing Glial cells Myotonic Dystrophy type 1 Muscle Skeletal muscle Antisense oligonucleotide GABA